5 edition of Chromatin Dynamics in Cellular Function (Results and Problems in Cell Differentiation) found in the catalog.
July 11, 2006
Written in English
|The Physical Object|
|Number of Pages||151|
Chromatin fibers are nucleosomal arrays bound to other nuclear order chromatin structure refers to folded and oligomeric nucleosomal arrays/chromatin fibers in vitro, and to levels of condensation beyond the 10 nm fiber in chromosomes in vivo. The central function of chromatin dynamics is to reveal, or block, access to specific DNA sequences in a manner that is dependent on the particular stage of the cell cycle, development, differentiation, and environment of the cell. In doing so, chromatin dynamics enables the cell to tightly regulate all the fundamental activities of the genome.
WCE, whole-cell extract. Bottom: nine chromatin state tracks, one per cell type, in a kb region centred at WLS, summarizing 90 chromatin tracks in . During the development of a multicellular organism, cell differentiation involves activation and repression of transcription programs that must be stably maintained during subsequent cell divisions. Chromatin remodeling plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate, a.
The high-order chromatin structure plays a non-negligible role in gene regulation. However, the mechanism for the formation of different chromatin structures in different cells and the sequence dependence of this process remain to be elucidated. As the nucleotide distributions in human and mouse genomes are highly uneven, we identified CGI forest and prairie genomic domains based . A eukaryotic cell is distinguished from a prokaryotic cell, by the presence of a distinct nucleus inside, which contains chromatin. Chromatin is a highly compressed and compactified form of genetic material. The main components of chromatin structure are DNA and various forms of histone proteins, that control the dynamics of genetic expression.
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About this book Introduction Topics covered include the structure and function of protein modules within chromatin-remodeling Chromatin Dynamics in Cellular Function book, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair.
Get this from a library. Chromatin dynamics in cellular function. [Brehon Curtis Laurent;] -- "This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field.
Topics covered include the structure and function of. Chromatin Dynamics in Cellular Function. Editors: Laurent, Brehon (Ed.) Free Preview. Buy this book eBook ,99 *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis.
ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. Electronic books: Additional Physical Format: Print version: Chromatin dynamics in cellular function.
Berlin ; New York: Springer, © (DLC) (OCoLC) Material Type: Document, Internet resource: Document Type: Internet Resource, Computer File:. Biochemical principles of the link from metabolism to chromatin. More than distinct covalent modifications have been identified on chromatin, DNA and RNA with many having substantially documented or emerging functional annotation 21–Among them, methylation, phosphorylation, ubiquitination, and acetylation are the most well understood, but less studied modifications including Cited by: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes.
The final chapters discuss the many ways chromatin. CHROMATIN DYNAMICS IN INTERPHASE NUCLEI. The dynamics of chromatin has long been of interest to geneticists and cell biologists.
For example, the question of whether chromosome rearrangements observed during the pairing of meiotic homologs in maize and Neurospora require a special motile machinery, or whether they move by diffusion, was first raised by Barbara McClintock in. Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes.
The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to. Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin.
Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile molecules that interact with nucleosomes as members of a dynamic protein network and serve as.
Locasale and co-authors discuss the influence of cellular metabolism on the regulation of chromatin and epigenetics. The substrates used to modify nucleic acids and chromatin are affected by. Cells have evolved to tightly link chromatin changes, and ultimately gene transcription, to changes in their environment by having chromatin-modifying factors dependent on metabolites for function.
Chromatin dynamics, in response to metabolic cues and thus metabolite availability, have large implications for a range of processes, including gene. Book Description. An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research.
Computational methods from statistical physics and bioinformatics are detailed whenever possible. Here we present our current understanding of how chromatin dynamics orchestrates DNA repair. We limit our discussion to eukaryotic model systems with a focus on yeast and mammalian cell systems.
We first introduce the major DNA repair pathways and how they operate within chromatin, with a focus on nucleotide excision repair (NER) and DNA double-strand break repair (DSBR).
The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.
The spatial segregation of prairies from forest indicates a phase separation mechanism in chromatin structure formation and remodeling, and the lineage specific interaction between the two types of DNA domains in cellular processes provides a new view on how cellular functions are achieved through the control of chromatin 3D structures.
Dynamic structural properties of chromatin play an essential role in defining cell identity and function. Transcription factors and chromatin modifiers establish and maintain cell states through alteration of DNA accessibility and histone modifications.
This activity is focused at both gene-proximal promoter regions and distally located regulatory elements. In the three-dimensional space of. Since chromatin structure, chromatin modifications and epigenetic signatures in stem cells are thoroughly covered by the other chapters in this book, I shall focus on introducing the concepts of live imaging and advanced microscopic techniques to study chromatin protein dynamics in living cells.
Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming Article Literature Review (PDF Available) in Genes 6(3) July with Reads How we measure 'reads'. Chromatin Dynamics in Cellular Function 作者: Laurent, Brehon C.
编 出版年: 页数: 定价: $ ISBN: 豆瓣评分. Chromatin dynamics in DSB repair. DSBs can occur in euchromatin (A, left panel) or heterochromatin (A, right panel).
In both cases, phosphorylation of H2AX occurs soon after DSB induction and is followed by recruitment of MDC1 and downstream repair factors as well as histone modifiers (B).
While roaming the nucleus, the HMGN proteins encounter binding partners and form metastable multiprotein complexes, which modulate their chromatin interactions. Studies with HMGN proteins underscore the important role of protein dynamics in chromatin words: HMG, nuclear proteins, chromatin, HMGN.Chromatin is a highly organized complex of DNA and proteins and is a principal component of the cell nucleus.
Histone proteins help organize DNA into structural units called nucleosomes, which are then assembled into a compact structure (chromatin) and eventually .Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 41) Neves-Costa A., Varga-Weisz P.
The Roles of Chromatin Remodelling Factors in Replication. In: Laurent B.C. (eds) Chromatin Dynamics in Cellular Function. Results and Problems in Cell Differentiation, vol Springer, Berlin, Heidelberg.